Back in the mid-1960s, while The Rolling Stones belted out “I Can’t Get No Satisfaction,” Dr. William S. Knowles was on the verge of a medical breakthrough — so big — that it would bring millions of people with Parkinson’s disease enormous satisfaction! At that time, it was known that the drug L-Dopa could help lessen the tremors associated with Parkinson’s. But for decades, production of L-Dopa was complex and costly because the molecular composition of L-Dopa is almost indistinguishable from the toxic D-Dopa. Dr. Knowles eventually devised the first practical lab technique for making the L form and avoiding the undesired D-Dopa form. According to his daughter, William S. Knowles died at his home in Chesterfield, Missouri. He had complications from Lou Gehrig’s disease. He was 95. Knowles’ body was cremated. A memorial service will be held at 2 p.m. June 30 at Episcopal Church of the Good Shepherd in suburban St. Louis. R.I.P.